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巴渝海外引智计划项目学术报告(周晓华教授)

2016-12-26 15:38:29  点击:[]

 

报告题目:Using the Treatment Benefit and Treatment Harm Rate to Assess the Heterogeneity of Treatment Effects

 

报告人:周晓华教授 美国华盛顿大学

 

主持人:邱世芳教授 重庆理工大学理学院

 

报告时间:201713日下午2:30

 

报告地点:理学院至善楼200

 

资助项目:重庆市巴渝海外引智计划项目

 

报告摘要:                          

 

In a clinical trial, statistical reports have been typically concerned about the mean difference between two groups. Now there is increasing interest in the heterogeneity of the treatment effect, which means that the same treatment can have different effects on different people. In this talk, I discuss our work on the treatment benefit rate (TBR) and the treatment harm rate (THR), which are defined as the proportion of people who have a better outcome on the treatment than the control and the proportion of people who have a worse outcome on the treatment than the control, respectively.  We first propose a relatively weak assumption to obtain bounds for the TBR and the THR, which are shown to always be better than the covariates adjusted simple bounds. Then we relax the current existing assumptions to identify the TBR and THR and derive the corresponding estimators.  We perform simulation studies to assess the performance of the proposed estimators and compare them with the proposed bounds. Finally, we illustrate the application of the proposed methods in a real-world, double-blinded, randomized clinical trial.

 

教授简介:晓华教授是美国大学公共生学院生物统计系教授,美国统计学会院士(ASA Fellow,美国FDA深咨询专家,国著名统计JASA, Statistics in medicine, Biometrics, Statistical Sinica的副主1999年当选为际统计研究院Elected Member2007年被美国邦政府退伍人事部授予研究生涯科学家2008年美国FDA会服务奖以及中国国家杰出海外青年学者基金得者等。主持(参与)了美国邦政府国家生研究院 (NIH)基金、美国国家科学基金(NSF)30个项目的研究。发表SCI论文200余篇,出版著“Statistical Methods in Diagnostic Medicine”。